Brenner, Ingrid

An athlete's psychological response to a sports-related concussion may influence thesuccess of recovery and return to play. This exploratory study explored how athletes psychologically respond to concussion, using Acceptance and Commitment Therapy to examine the role of psychological flexibility in recovery and return to play. Thirty athletes who experienced a concussion in the past three months completed online surveys measuring symptom severity, sport confidence, psychological strain, anxiety, depression, and psychological flexibility. Depression significantly predicted symptom severity (β = .615, p = .015). Psychological flexibility improved from pre- to post-return to play (p = 0.032, d = 0.45) and was correlated with greater confidence (pre: r = –0.451; post: r = – 0.577) and lower psychological strain (r = 0.471). These findings suggest that increasing psychological flexibility may enhance recovery by reducing distress and building confidence. Return-to-play protocols should include psychological recovery measures.

Author Keywords: Concussion, Injury Recovery, Psychological Flexibility, Return to Play

Heart failure (HF) is a condition with several possible etiologies that influence patient symptomatology, including response to exercise. The purpose of this review was to assess how cardiopulmonary exercise testing (CPET) parameters used for risk stratification differ and are associated with mortality and adverse cardiac events in patients with different HF etiologies. We completed a systematic review of studies that assessed CPET data in adult heart failure patients and reported outcomes of mortality, left ventricular assist device implantation, heart transplantation, or hospitalization. Interestingly, the optimal threshold values derived from CPET were strikingly similar for stratifying risk in patients with different HF etiologies. Even with heterogeneity in the data, the literature suggests that optimal threshold values from CPET can be applied generally without consideration of HF etiology. However, there is a need to consider a broader spectrum of HF etiologies and CPET parameters in larger and more representative study populations.

Author Keywords: Cardiopulmonary Exercise Testing, Etiology, Heart Failure, Ischemic Cardiomyopathy, Non-Ischemic Cardiomyopathy, Prognosis

Objectives/purpose: The current study examined whether attending a 1-month virtual oncology camp (VOC) improved resilience and hope in childhood cancer patients and parental/caregiver stress.

Methods:Childhood cancer patients/survivors and their parent/caregivers enrolled for VOC, participated in an online anonymous survey: before, after and 3-months after VOC. The survey included the Child and Youth Resilience Measure (CYRM) and the Snyder's Children's Hope Scale (CHS) for the childhood cancer patients/survivors and the Pediatric Inventory for Parents (PIP) for parent/caregivers.

Results:CYRM scores increased from T1 to T2 (d=0.86). Compared to T1, at T2 CHS scores also increased (d=1.33). Both CHS and CYRM scores remained higher at T3 compared with T1 (d=1.34; d=0.86). There were no changes in PIP scores between any time points.

Conclusion and significance: Our study demonstrated that participation in a VOC improved children's resilience and hope but did not change parental stress. Highlighting the clinical significance of these VOCs and the impacts they have on childhood cancer patients/survivors.

Author Keywords: cancer, children, hope, parental stress, resilience, virtual oncology camp

This study investigated the role of the JNK signaling pathway in cadmium-treated mouse embryo forelimb bud cells in vitro. Primary cultures of forelimb bud cells harvested at day 11 of gestation were pre-treated with JNK inhibitor SP600125, and incubated with or without CdCl2 for 15, 30, 60, 120 minutes and 24, 48 hours or 5 days. Endpoints of toxicity were measured through cell differentiation by Alcian Blue Assay and phosphorylation of JNK proteins by Western blot. The results demonstrated that, in the cell differentiation assay, inhibiting JNK activation by 20 μM SP600125 causes an enhanced toxic effect in limb cells and inhibits cell differentiation, whereas 2 μM decreases differentiated nodule numbers under both cadmium stress and normal conditions. In conclusion, the JNK pathway has an essential role in the differentiation processes of limb bud cells in normal growth conditions.

Author Keywords: Cadmium, Cell Signaling, JNK, Limbs, Mouse Embryo, Teratology