Trent University Graduate Thesis Collection

Item Description
Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
Rights
Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Evaluation of silver nanoparticles (AgNPs) and anti-GD2-AgNP antibody-drug conjugates as novel neuroblastoma therapies

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Year: 2018, 2018
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): MacLeod, Haley Ann, Thesis advisor (ths): Brunetti, Craig R, Degree committee member (dgc): Kaplan, David R, Degree committee member (dgc): Kerr, Leslie R, Degree granting institution (dgg): Trent University
Abstract: <p>Neuroblastoma (NB) has one of the highest mortality rates in pediatric oncology due to relapsed and refractory disease. Current aggressive multi-modal treatments are inhibited by dose-limiting toxicities and are associated with late-effects and secondary malignancies, emphasizing the necessity for novel therapeutics. Uniquely, most NB cells highly express disialoganglioside (GD2) a cell… more