Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Evidence suggests that visuomotor system behaviour may be more sensitive to the prolonged effects of mild brain injuries than neuropsychological tests. We evaluated whether participants with a mild closed head injury (CHI) would show lingering visuomotor deficits, but not cognitive deficits, up to three years post-injury compared to participants with an orthopaedic injury and healthy… more Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Cognitive impairments, such as memory loss, are a frequent and devastating co-morbidity associated with epilepsy. The neurobiological mechanisms through which recurrent seizures induce cognitive impairments are not well understood. New neurons born after seizures develop abnormal morphological and functional characteristics that promote network hyperexcitability and hippocampal… more Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Seizures induce long-term changes in gene expression in the hippocampus. Experimental evidence has demonstrated a significant effect of epileptic activity on the activity of neurons that participate in complex cognitive and behavioural processes. The present series of experiments involving kindling with subconvulsive doses of PTZ demonstrates a link between seizures and altered immediate… more Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Distributing contextual fear episodes makes the memory become HPC-independent, meaning increasingly reliant on non-HPC memory structures. It is unclear, however, whether distribution of the conditioning episodes alone is sufficient or whether a combination of distribution and high conditioning saliency is necessary to make the memory become HPC-independent. To resolve this issue, rats… more
