Trent University Graduate Thesis Collection

Item Description
Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
Rights
Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Expression of Giardia intestinalis flavoenzyme GiOR-1 and characterization of its electron transfer properties

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Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Villeneuve, Tiffany C., Thesis advisor (ths): Rafferty, Steven, Degree committee member (dgc): Huber, Robert, Degree committee member (dgc): Brunetti, Craig, Degree granting institution (dgg): Trent University
Abstract: <p>Giardia intestinalis possesses four isotypes of cytochrome b5 (gCYTB-I-IV) that differ from their mammalian counterparts, suggesting different functions in this protozoan parasite. Although the recently discovered Giardia flavoenzyme, GiOR-1, reduces these cytochromes, its properties have not been thoroughly studied, owing to the difficulty in its expression. Here I describe successful… more

Fungal pathogen emergence: an Ustilago maydis x Sporisorium reilianum model

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Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Storfie, Emilee, Thesis advisor (ths): Saville, Barry, Degree committee member (dgc): Donaldson, Michael, Degree committee member (dgc): Huber, Robert, Degree granting institution (dgg): Trent University
Abstract: <p>The emergence of fungal hybrid pathogens threatens sustainable crop production worldwide. To investigate hybridization, the related smut fungi, Ustilago maydis and Sporisorium reilianum, were selected because they infect a common host (Zea mays), can hybridize, and tools are available for their analysis. Hybrid dikaryons exhibited filamentous growth on plates but reduced virulence and… more

Immunotherapies Targeting the Amyotrophic Lateral Sclerosis-Associated Protein TDP-43

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Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Esposto, Josephine, Thesis advisor (ths): Martic, Sanela, Degree committee member (dgc): Rafferty, Steven, Degree committee member (dgc): Huber, Robert, Degree granting institution (dgg): Trent University
Abstract: <p>Transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) pathology, including fibrillar aggregates and mutations, develops in amyotrophic lateral sclerosis (ALS) and is characterized by hyperphosphorylation and aggregation patterns, a mechanism largely understudied. In addition, ALS remains without a cure. Herein, in vitro aggregation of phosphorylated TDP-43 was explored, and… more