Trent University Graduate Thesis Collection

Item Description
Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
Rights
Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Frog Virus 3: Tracking Viral Spread using Molecular Tools

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Year: 2018, 2018
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Grant, Samantha Adrianna, Thesis advisor (ths): Kyle, Christopher J, Thesis advisor (ths): Brunetti, Craig R, Degree committee member (dgc): Wilson, Chris C, Degree granting institution (dgg): Trent University
Abstract: <p>Understanding the maintenance and spread of invasive diseases is critical in evaluating threats to biodiversity and how to best minimize their impact, which can by done by monitoring disease occurrences across time and space. I sought to apply existing and upcoming molecular tools to assess fluctuations in both presence and strain variation of frog virus 3 (FV3), a species of Ranavirus,… more

Evaluation of silver nanoparticles (AgNPs) and anti-GD2-AgNP antibody-drug conjugates as novel neuroblastoma therapies

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Year: 2018, 2018
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): MacLeod, Haley Ann, Thesis advisor (ths): Brunetti, Craig R, Degree committee member (dgc): Kaplan, David R, Degree committee member (dgc): Kerr, Leslie R, Degree granting institution (dgg): Trent University
Abstract: <p>Neuroblastoma (NB) has one of the highest mortality rates in pediatric oncology due to relapsed and refractory disease. Current aggressive multi-modal treatments are inhibited by dose-limiting toxicities and are associated with late-effects and secondary malignancies, emphasizing the necessity for novel therapeutics. Uniquely, most NB cells highly express disialoganglioside (GD2) a cell… more