Trent University Graduate Thesis Collection

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tula:etd

Type

Collection

Language

eng

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1 item

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Displaying 1 - 6 of 6

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Displaying 1 - 6 of 6

Characterization of a Zn(II)2Cys6 transcription factor in Ustilago maydis and its role in pathogenesis

Year: 2019, 2019

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): Cheung, H.Y. Kitty, Thesis advisor (ths): Saville, Barry J, Degree committee member (dgc): Brunetti, Craig R, Degree committee member (dgc): Emery, R.J. Neil, Degree granting institution (dgg): Trent University

Abstract: Ustilago maydis (D.C.) Corda is a biotrophic pathogen that secretes effectors to establish and maintain a relationship with its host, Zea mays. In this pathosystem, the molecular function of effectors is well-studied, but the regulation of effector gene expression remains largely unknown. This study characterized Zfp1, a putative U. maydis Zn(II)2Cys6 transcription factor, as a modulator… more

Frog Virus 3: Tracking Viral Spread using Molecular Tools

Year: 2018, 2018

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): Grant, Samantha Adrianna, Thesis advisor (ths): Kyle, Christopher J, Thesis advisor (ths): Brunetti, Craig R, Degree committee member (dgc): Wilson, Chris C, Degree granting institution (dgg): Trent University

Abstract: Understanding the maintenance and spread of invasive diseases is critical in evaluating threats to biodiversity and how to best minimize their impact, which can by done by monitoring disease occurrences across time and space. I sought to apply existing and upcoming molecular tools to assess fluctuations in both presence and strain variation of frog virus 3 (FV3), a species of Ranavirus,… more

Evaluation of silver nanoparticles (AgNPs) and anti-GD2-AgNP antibody-drug conjugates as novel neuroblastoma therapies

Year: 2018, 2018

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): MacLeod, Haley Ann, Thesis advisor (ths): Brunetti, Craig R, Degree committee member (dgc): Kaplan, David R, Degree committee member (dgc): Kerr, Leslie R, Degree granting institution (dgg): Trent University

Abstract: Neuroblastoma (NB) has one of the highest mortality rates in pediatric oncology due to relapsed and refractory disease. Current aggressive multi-modal treatments are inhibited by dose-limiting toxicities and are associated with late-effects and secondary malignancies, emphasizing the necessity for novel therapeutics. Uniquely, most NB cells highly express disialoganglioside (GD2) a cell… more

Characterisation of the Giardia Tata-Binding Protein - Preparation for an in vivo approach

Year: 2016, 2016

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): Kemp, Adam, Thesis advisor (ths): Yee, Janet, Degree committee member (dgc): Saville, Barry J, Degree committee member (dgc): Brunetti, Craig R, Degree granting institution (dgg): Trent University

Abstract: The aim of this work was to identify the DNA sequences recognized by the Giardia TBP (gTBP) in vivo by using a chromatin immunoprecipitation assay (ChIP). Since a specific antibody for the protein of interest is required for this assay, a company was contracted to produce and purify a custom polyclonal antibody from the immunization of rabbits. Recombinant GST-gTBP was produced at a… more

Characterization of frog virus 3 and its binding partner LITAF

Year: 2015, 2015

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): Lacerda, Andressa, Thesis advisor (ths): Brunetti, Craig R, Degree committee member (dgc): Saville, Barry, Degree committee member (dgc): Kapron, Carolyn, Degree granting institution (dgg): Trent University

Abstract: Iridoviruses are large (120-200nm) double stranded DNA viruses that contain an icosahedral capsid. The iridoviridae family is composed of five genera that infect a wide range of poikilothermic vertebrates (Lymphocystivirus, Ranavirus and Megalocyivirus) and invertebrate hosts (Iridovirus, Chloriridovirus). Frog virus 3 (FV3) is a member of the Ranavirus genus, and is commonly used as a… more

Genome annotation, gene characterization, and the functional analysis of natural antisense transcripts in the fungal plant pathogen Ustilago maydis

Year: 2014, 2014

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): Donaldson, Michael Edward, Thesis advisor (ths): Saville, Barry J, Degree committee member (dgc): Brunetti, Craig R, Degree committee member (dgc): Yee, Janet, Degree granting institution (dgg): Trent University

Abstract: <italic>Ustilago maydis</italic> (DC) Corda is the causal agent of 'common smut of corn'. Completion of the <italic>U. maydis</italic> lifecycle is dependent on development inside its host, <italic>Zea mays</italic>. Symptoms of <italic>U. maydis</italic> infection include chlorosis and the formation of tumours on all aerial corn… more