Graduate Theses & Dissertations

Pages

Use Of Rapid Amygdala Kindling With Corticosterone Supplementation As A Model Of Epilepsy-Depression Comorbidity
Temporal lobe epilepsy increases risk for developing major depression, and conversely, depression increases risk for development of epilepsy. The mechanisms responsible for the widely observed bi-directional relationship between epilepsy and depression are currently poorly understood. One reason why our understanding of shared etiology has had little improvement is due to the lack of availability of a reliable animal model for inducing depression in epileptic animals. The development of a reliable model of epilepsy-depression comorbidity would greatly improve the ability to mechanistically evaluate shared pathophysiology between the conditions. Recently there has been evidence that rapid kindling of the basolateral amygdala can evoke a behavioural phenotype that is comparable to the symptoms of anxiety and depression observed in depressed epileptic patients. However, this work has yet to be replicated, leaving question as to whether or not the behavioural phenotype can be reliably evoked. In the following series of experiments we assessed rapid amygdala kindling as a potential model of epilepsy-depression comorbidity and sought to improve the model with inclusion of the glucocorticoid corticosterone. Our findings may improve our understanding of the unique relationships between epilepsy and depression. Author Keywords: animal models, depression, hippocampus, kindling, stress, temporal lobe epilepsy
Influence of Action Potentiation on the Perception of Objects Presented Near Hand
For currently-debated reasons, perception of visual stimuli is enhanced in near-hand space compared to far-hand space. According to the action potentiation hypothesis, near-hand effects result from automatically generated potential motor responses produced upon viewing objects presented in near-hand space. This hypothesis was tested by crossing hand manipulations with two separate techniques designed to elicit action potentiation. The first series of experiments presented participants with a cueing task where images of handled objects served as the cue, and its handle compatibility was manipulated. A consistent near-hand effect was observed, but there was no evidence that the images potentiated action as there was no handle-compatibility effect. The second experiment used a visuomotor competition reaching task, which required participants to initiate reaches toward a distractor display and adjust their trajectory on the fly so as to end the reach at a later indicated target location. For every distractor presented simultaneous and competing motor responses were generated, and differences in how hand presence influenced the resolution of this competition were examined. Based on predictions made, action potentiation is unlikely to be the root cause of the near-hand effect; however, was not possible to rule out this explanation entirely. The findings of these experiments shed light both on the importance and consistency of the near-hand effect, and the difficulties associated with uncovering its nature in human populations. Author Keywords:
Problem-Solving and Cognitive Flexibility in Older Adolescents and Young Adults
Ill-structured problems have changing components that solvers need to adapt their solutions to. Well-structured problems have strict, well-defined procedures, and solvers must know which procedures to apply and when. Research has suggested that these two types of problems utilize different problem-solving skills. The current study focused on the relation between ill-structured interpersonal problem solving, novel well-structured problem-solving, and cognitive flexibility in young adults and older adolescents. It was predicted that because of the changing components of ill-structured problems, cognitive flexibility would more strongly predict these compared to well-structured problems. The current study sample consisted of 73 undergraduates with an average age of 20.43 years. The results showed that cognitive flexibility is equally associated with ill-structured problem-solving and well-structured problem-solving. This suggests that cognitive flexibility may support the perspective coordination involved in solving ill-structured problems and that cognitive flexibility may support switching between search strategies when solving a novel well-structured problem. Author Keywords: adolescent, adult, cognitive flexibility, ill-structured problem-solving, novel problems, well-structured problem-solving
Effect of Aging and Movement Variability on Motor Adaptation
Aging is associated with a multitude of changes, including changes in the motor system. One such change that has been documented is increased levels of inherent movement variability (the inability to consistently replicate movements over time) with increasing age. Previous research has had controversial findings regarding the effect that movement variability has on motor learning and motor adaptation. Some research suggests that movement variability is beneficial to motor learning, while other research indicates that movement variability is the by-product of a noisy motor system and is a detriment to learning new skills. How do changes in movement variability associated with aging affect the ability to adapt to a mass perturbation? We tested younger and older individuals on a mass adaptation task (applying mass to the lateral side of the arm to perturb inertial forces of the limb during reaches). We analyzed baseline levels of movement variability, learning during the adaptation block and how baseline levels of movement variability explained differences in learning. We focused on measures of accuracy, speed and precision. We found that younger individuals displayed greater levels of movement variability throughout the experiment and that they also learned to adapt to the mass perturbation more successfully than their older counterparts. Multi-joint movements displayed greater degrees of learning in comparison to single-joint movements, likely due to the difference in difficulty when completing the two movements. Taken together, our results suggest that purposeful movement variability may be beneficial to motor adaptation. Author Keywords: aging, mass adaptation, motor adaptation, motor learning, movement variability
What Nature is Best?
Connecting with nature benefits human and environmental health, however it is unclear whether certain types of nature influence people differently. Research has primarily focused on green spaces (vegetation-rich areas), but recent cross-sectional studies suggest that green spaces with blue space (natural water elements) may have additional well-being benefits. A quasi-experimental design compared the effects of green spaces with or without water on mood and environmental concern. Students (N = 193) were randomly assigned to walk along campus green (drumlin) or blue (river) spaces. Both walks improved students’ mood, especially for those who had a stronger preference for the area. Students in both conditions reported more sustainable behaviours when followed up one week and one month later, but decreased in nature contact and well-being. These findings highlight the challenges of promoting regular nature contact as a mood regulation strategy. Implications and future directions are discussed. Author Keywords: blue space, green space, nature connectedness, well-being
Problem Solving as a Path to Understanding Mathematics Representations
Little is actually known about how people cognitively process and integrate information when solving complex mathematical problems. In this thesis, eye-tracking was used to examine how people read and integrate information from mathematical symbols and complex formula, with eye fixations being used as a measure of their current focus of attention. Each participant in the studies was presented with a series of stimuli in the form of mathematical problems and their eyes were tracked as they worked through the problem mentally. From these examinations, we were able to demonstrate differences in both the comprehension and problem-solving, with the results suggesting that what information is selected, and how, is responsible for a large portion of success in solving such problems. We were also able to examine how different mathematical representations of the same mathematical object are attended to by students. Author Keywords: eye-tracking, mathematical notation, mathematical representations, problem identification, problem-solving, symbolism
Social Anxiety and Emotional Competence
Prior research has examined social anxiety, emotional competence (EC) and life adjustment (i.e., loneliness and life satisfaction) using cross-sectional designs, although there is limited information on their association over time. The present study examined the impact of social anxiety on life adjustment and assessed if EC could mediate this relationship from young to middle adulthood. University students (N = 283) completed self-report measures at two time points: in first year university and 15 years later. The results accord with previous research demonstrating the stability and slight decrease of social anxiety over time. Social anxiety in young adulthood was a robust predictor of loneliness in middle adulthood, and a weak predictor of life dissatisfaction for men. Mediation analyses revealed that social anxiety was indirectly associated with interpersonal adjustment via EC, especially the intrapersonal EC domain. Social anxiety requires early intervention and EC may help to prevent later social anxiety and maladjustment. Author Keywords: emotional intelligence, life adjustment, social anxiety
It's All in Your Head
The Continuity Hypothesis states that dreams reflect waking day cognition and experiences, which reflect one’s mental health status. As such, dreams are, by extension, cognitions that occur during sleep. To date, Cognitive Behavioural Therapy (CBT) is deemed the most efficacious method of social anxiety treatment by working with cognitions. The current study utilized both CBT and The Storytelling Method (TSM) of dream interpretation, whose methodology is based on CBT; CBT works with waking cognitions and TSM works with sleep cognition. This study examined the effectiveness in decreasing social anxiety symptoms with TSM and comparing its efficacy to a traditional CBT technique. Undergraduate psychology students (N = 36) completed a daily journal of either the TSM or CBT format for two weeks. Participants completed self-report measures of social anxiety, state-anxiety, and depression before and after practicing either method. TSM did not significantly decrease levels of social anxiety, state-anxiety, or depression, whereas CBT significantly decreased only social anxiety levels. Dream content reflecting waking day anxiety and depression did not decrease over time, coinciding with the findings that students did not experience a decrease in their waking day life, supporting the Continuity Hypothesis. Findings suggest anxiety and depression to be very stable in this sample. Future research should explore interventions that are clinician-guided, in a group setting, or, occur over a longer period of time. Author Keywords: Content Analysis, Social anxiety, The Storytelling Method
Academic Procrastination, Self-Regulation, Anxiety and Personality (ASAP)
Academic procrastination is analogous to a common cold: pervasive and with no established cure. Students experience repercussions that are not inclusive to academic performance, but rather, are experienced across mental, physical, social and emotional domains as well. While this necessitates treatment, much of the behaviour has yet to be explained. In the current study, a state approach was integrated to explore procrastination in terms of the Yerkes-Dodson paradigm. Procrastination was hypothesized to arise for one of two reasons: students are either too low or too high in anxiety. A sample of 847 Ontario undergraduate students completed measures of procrastination, state-anxiety, personality, and self-regulation. Results suggest 88% of students procrastinate regularly, and contrary to what was hypothesized, procrastination and anxiety were linearly related. Independent t-tests establish that relative to non-procrastinators, procrastinators are significantly more emotionally and biologically dysregulated and less socially integrated. Factor analysis demonstrated three central reasons contributing to procrastination, which were used as the basis to establish types of procrastination: social (n=61), self-doubt (n=70) and low-energy (n=76) procrastinators. Results indicate divergences across procrastination type with respect to personality as well as biological, affective and social domains. Findings also inform that the expression of procrastination, varies across student. Overall, findings suggest that academic interventions should acknowledge and address the variability among procrastinators. Author Keywords: ACADEMIC PROCRASTINATION, ANXIETY, PERSONALITY, SELF-REGULATION
Comparison of Dehydration Techniques for Acute Weight Management in Rowing
Mild sauna dehydration and fluid abstinence were investigated as weight loss strategies for lightweight rowers. Rowers (N=12) performed a power test, an incremental VO2max test, and a visuomotor battery: once euhydrated, once following sauna dehydration (SAU), and once following fluid abstinence and then sauna dehydration (FA). The percent body mass change (%BMC) achieved, %BMC attributable to sauna dehydration, and %BMC attributable to fluid abstinence were used within linear mixed effects models to predict hydration and performance variables. Sauna and overnight dehydration exerted indistinguishable effects on plasma osmolality, urine osmolality and thirst (p > .05). Fluid abstinence but not sauna dehydration was related to lower power production on the power test (b = 12.14W / 1%BMC, FA = 673.46 ± 79.50, SAU = 683.33 ± 72.08, p = .029), a lower total wattage produced on the incremental VO2max test (b = 4261.51W / 1%BMC, FA = 71029.58 ± 16256.56, SAU = 74001.50 ± 14936.56, p = .006), lower wattages at 2 mmol/L (b = 27.84W / 1%BMC, FA = 180.74 ± 40.27, SAU = 190.82 ± 50.79, p < .001) and 4 mmol/L (b = 20.45W / 1%BMC, FA = 221.90 ± 52.62, SAU = 238.89 ± 40.78, p = .002) blood lactate, and slower movement time on a visuomotor task (b = -38.06ms / 1%BMC, p = .004). Mild fluid abstinence but not sauna dehydration reduces rowing performance when two-hour rehydration is allowed. Author Keywords: crew, fluid, hydration, lightweight, sauna, weight
Impaired contextual fear discrimination learning after long-term amygdala kindling
Cognitive impairments, such as memory loss, are a frequent and devastating co-morbidity associated with epilepsy. The neurobiological mechanisms through which recurrent seizures induce cognitive impairments are not well understood. New neurons born after seizures develop abnormal morphological and functional characteristics that promote network hyperexcitability and hippocampal dysfunction. Previously, we found that kindling dramatically increases the rate of neurogenesis at early stages of seizure development, followed by a long-term suppression at later stages. These changes in the rate of cell proliferation coincides with aberrant modifications in the migration, excitability, and functional integration of these new neurons. It has been suggested that the long-term consequences of seizure-induced neurogenesis contributes to the development of cognitive impairment seen in chronic epilepsy. However, direct experimental evidence has been limited. The present series of experiments sough to determine if blocking aberrant seizure-induced neurogenesis can reduce cognitive deficits associated with chronic epilepsy. Our findings suggest that chronic seizures impair the ability of rats to differentiate between similar contexts. In addition, blocking aberrant seizure-induced neurogenesis through treatment with the cytotoxic agent temozolomide was capable of preventing some of the deficits in context discrimination learning when neurogenesis levels were reduced to non-epileptic control levels. This research provides further support of targeting aberrant neurogenesis as a novel treatment to restore cognitive functioning in individuals living with epilepsy. Author Keywords: Amygdala kindling, Dentate gyrus, Hippocampus, Neurogenesis, Pattern separation, Seizures
To Sext or Not to Sext
The risks and benefits of sexting within an intimate relationship were explored. The present study focused on sexual gratification, relationship benefits, and sexual communication as benefits and risky sexual behaviour, unethical forwarding, and infidelity as risks. A cross-sectional online survey of both undergraduate students and a community sample was used. Results indicated that sexual gratification, relationship benefits (sexual and relationship satisfaction, relationship quality, and commitment), and sexual communication are related to sexting. It appears that risky sexual behaviour is not associated with sexting, instead those who sext frequently engage in more safer sex behaviours than those who sext infrequently. Unethical forwarding does not appear to happen very often in the context of intimate relationships. Lastly, the current research indicates that some participants are sexting secondary partners, and many consider sexting secondary partners infidelity. These results show that there are both risks and benefits of sexting, which can be used to develop sext education and therapeutic programs. Author Keywords: infidelity, relationship benefits, Sexting, sexual behaviour, sexual communication, sexual gratification

Pages

Description

Graduate student theses produced at Trent University. You may also browse theses and dissertations by year, program, or author.

In collections

Search Our Digital Collections

Query

Enabled Filters

  • (-) ≠ Biogeochemistry
  • (-) = Psychology

Filter Results

Date

2004 - 2024
(decades)
Specify date range: Show
Format: 2024/05/15

Collection

Author Name

Show more

Name (Any)

Show more

Degree

Degree Discipline

Subject (Topic)

Show more