Graduate Theses & Dissertations

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Altered Hippocampal Regulation of Immediate Early Genes after Pentylenetetrazol-Induced Seizures
Seizures induce long-term changes in gene expression in the hippocampus. Experimental evidence has demonstrated a significant effect of epileptic activity on the activity of neurons that participate in complex cognitive and behavioural processes. The present series of experiments involving kindling with subconvulsive doses of PTZ demonstrates a link between seizures and altered immediate early gene expression within the hippocampus and dentate gyrus. In addition, newborn hippocampal neurons were shown to have decreased induction of plasticity-related genes, suggesting deficits in activity-dependent recruitment. These findings may shed light on the mechanisms underlying epileptogenesis and epilepsy-related hippocampal dysfunction in human patients. Author Keywords: hippocampus, IEGs, kindling, neurogenesis, seizures
An Emergent Model of the Return to Learn Process for Adolescents with Prolonged Concussion
Current literature on concussion management focuses primarily on the return to physical activity, while the return to learn process is less clearly understood. This knowledge gap is particularly problematic for adolescents, whose primary responsibility is academics. The present study sought to develop a more in-depth understanding of the return to learn process through the perspectives of adolescents who had sustained a concussion and their parents in in-person, semi-structured interviews. A substantive grounded theory of the return to learn process for adolescents that emerged from the data is provided. The basic model is consistent with many speculative, non-empirically based concussion management protocols, but extends these models by emphasizing the central role of parents in managing their child’s recovery process, highlighting the importance of role fulfillment within the concussion management network, and identifying the impact of the adolescent’s capacity and readiness for help-seeking. The results also highlight the vulnerability of concussed adolescents to losing their support structure as they move through key school transitions. Implications for educators, medical professionals, parents, and adolescents in the return to learn process are also discussed. Author Keywords: Adolescent, Concussion, Concussion Management, Multidisciplinary Management, Return to Learn, Return to School
An Exploration of Attachment Influences on Rape Attitudes
While there is substantial research on the influence of adverse childhood experiences on sexual offending behaviours and attachment representations on sexual offending behaviours, few studies to date have explored how adverse childhood experiences and attachment representations act together to influence the development of rape attitudes in a non-clinical population. The purpose of this thesis was to explore how childhood experiences and attachment may help to understand the development of rape attitudes. Data were collected from 273 undergraduate students who completed self-report questionnaires pertaining to their attachment, childhood experiences and rape attitudes. Correlational and Structural Equation analyses were computed, and the results did not find support for the simultaneous influence of adverse childhood experiences and attachment representations on rape attitudes. Given that the sample was primarily female (83%), the results indicate that the outcomes of adverse childhood experiences on sexual attitudes may differ by gender. Understanding the formation of rape attitudes is important to understand the motivations behind sexual assault behaviours. Author Keywords: adverse childhood experiences, rape attitudes
Anti-Social Cognition
Callousness, deceit, and manipulativeness have been identified as common characteristics of the Dark Triad. Researchers have argued that empathy and Theory of Mind underlie these characteristics. This study aimed to (a) examine the relationships between the Dark Triad, empathy, and Theory of Mind, (b) determine if empathy and Theory of Mind explain the overlap between the Dark Triad personalities, and (c) test if Theory of Mind mediated the relationship between cognitive empathy and the Dark Triad. A sample of 267 undergraduate students completed self-report scales and a film-based assessment to measure the variables of interest. The results indicated that the Dark Triad personalities were negatively associated with affective empathy but were not uniformly associated with cognitive empathy and Theory of Mind. Affective empathy did not explain the overlap between the Dark Triad personalities. Finally, Theory of Mind did not mediate the relationship between cognitive empathy and the Dark Triad. Author Keywords: Dark Triad, Empathy, Mediation, Theory of Mind
Application of the Sexual Self-Control Model and the Two-Dimensional Sexual Double Standard Scale to Heterosexual Undergraduate Men and Women
This thesis examined the applicability of the sexual self-control model to men, which resulted in the creation and analysis of a new two-dimensional sexual double standard scale. In Study 1, a sample of 124 men completed the Self-Control Schedule assessing general learned resourcefulness, the Sexual Resourcefulness Inventory, Sexual Self-efficacy Scale, Reasons for Consenting to Unwanted Sexual Advances Scale, and the Sexual Giving-in Experiences Survey. Contrary to expectations based on female samples, lower sexual resourcefulness was not a unique predictor of consenting to unwanted sexual advances in men. Instead, a mediation model was supported whereby men having more reasons for consenting to unwanted sexual advances were more likely to comply despite having higher levels of sexual resourcefulness skills. Concurrent with Study 1, 11 men were interviewed in Study 2 to further examine their giving-in to unwanted sexual advances, reasons for consenting, and sexual resourcefulness, but men shifted the conversation toward the sexual double standard despite scoring neutral to a quantitative sexual double standard measure in the survey of Study 1. Therefore, a new sexual double standard scale was created based on the content of the interviews. Study 3 examined the new scale's psychometric properties and its association with sexual consenting. The findings revealed that the new scale was best represented by two dimensions: personal attitudes and peer responses. Neither of these two subscales uniquely predicted giving-in to unwanted sexual advances, but were significantly associated with several key variables differentially. Author Keywords: learned resourcefulness, sexual double standard, sexual health, sexual resourcefulness, sexual script theory, unwanted sex
Assessing Emotion Processing Deficits in Youth
It is well-established that alexithymia in adulthood is a critical risk factor for numerous negative mental health and well-being outcomes. Although this area of research has begun to receive interest in earlier developmental stages, significant methodological limitations have been noted with current measures of alexithymia for adolescence. As such, the aim of the current thesis was to provide empirical evidence on the psychometric strength of a new adolescent measure of alexithymia, the Toronto Alexithymia Scale – Adolescent Version (TAS-A). Study 1 examined the construct validity of the TAS-A in relation to self and informant reported emotional intelligence (EI), while study 2 examined the predictive validity of the TAS-A in relation to adolescent problematic gambling and academic achievement. Adolescents completed self-reports of alexithymia, EI, and gambling behaviour, parents completed informant reports regarding their child’s EI, and academic records were obtained. Confirmatory factor analyses revealed significant relationships between adolescent alexithymia, and self and informant reported EI, indicating significant overlap in constructs. Adolescent alexithymia was also shown to be a significant predictor of problematic gambling and academic achievement; however, some interesting gender differences were observed (a pattern of results reported consistently in the adult alexithymia literature). Results are discussed in terms of methodological and clinical implications during the vulnerable developmental transition of adolescence. Author Keywords: adolescence, alexithymia, psychometrics
Cognitive Inefficiencies in Adolescents with Eating Disorders
Eating Disorders (ED) are notoriously difficult to treat due, in part, to commonly observed inefficiencies in cognitive flexibility and central coherence, which are believed to maintain disordered cognitions and behaviours and negatively impact prognosis. Cognitive remediation therapy (CRT) has recently been used effectively with adults with ED; however, evidence among adolescents is limited. The present study explored change in flexibility and central coherence in a group of 23 adolescent ED inpatients (M = 16 years, SD = 0.95). All participants received a comparable dose of ED treatment. Participants were split into two groups for comparison: the CRT group (n = 15) received CRT in addition to TAU; and a TAU group for control (TAU; n = 8). Improvements in flexibility and central coherence were superior in the CRT group, suggesting that CRT is a potentially useful treatment for adolescents with AN as part of an overall psychosocial rehabilitation program. Author Keywords: anorexia nervosa, central coherence, cognitive flexibility, cognitive remediation, eating disorders, set shifting
Context Fear Memory
Distributing contextual fear episodes makes the memory become HPC-independent, meaning increasingly reliant on non-HPC memory structures. It is unclear, however, whether distribution of the conditioning episodes alone is sufficient or whether a combination of distribution and high conditioning saliency is necessary to make the memory become HPC-independent. To resolve this issue, rats were trained using a distributed contextual fear conditioning protocol in which foot-shocks were manipulated to create a low (0.4mA), intermediate (0.7 mA) and high (1.0 mA) saliency condition. This thesis also aimed to determine brain structures supporting the HPC-independent memory by assessing retention-induced c-fos expression in the basolateral- amygdala, perirhinal and anterior cingulate cortices. The results suggest that HPC lesion rats in the high saliency condition displayed similar level of freezing as control rats, indicating “strongly salient” and distributed episodes creates a HPC independent memory. c-fos expression suggests together, an increased context representation in the perirhinal and anterior cingulate cortices and a strengthened fear representation in the basolateral-amygdala supports the HPC-independent memory. Author Keywords: context fear memory, distributed reinstatements, hippocampus, IEG, rat, saliency
Developing social skills
Guidelines regarding social skills interventions for children with ASD suggest incorporating a holistic approach. This includes increasing the family’s understanding of deficits associated with ASD, integrations of natural environments, and parents as active agents while supporting their well-being. The current availability of holistic parent-mediated interventions for children with ASD is limited, with no qualitative understanding of its potential benefits for either the parent or child. The current study examined qualitative parent reports on a parent-mediated social skills intervention for children with ASD (TalkAbilityTM) incorporating a longitudinal approach (i.e., 6-month follow-up). Following Braun and Clarke’s model of thematic analysis, data was coded into four themes: 1) communication difficulties, frustrations and progress, 2) social relationships and concerns, 3) communication strategies, and 4) thoughts and emotions surrounding TalkAbilityTM. Results highlight the importance of considering parent experiences regarding interventions for their child’s social communication skills through a qualitative viewpoint. Author Keywords: autism spectrum disorder, parent-mediated intervention, qualitative review
Does boredom lead to ego-depletion? Examining the association between boredom and ego-depletion
Ego-depletion refers to the observation that using self-control at Time 1 (T1) in the sequential-task paradigm leads to worse self-control at Time 2 (T2; Baumeister et al., 1998). Self-control is often manipulated by varying the difficulty of the task used at T1. Recently, Wolff and colleagues (2020) suggested that failures to replicate the ego-depletion phenomenon may arise because simple tasks may be boring, therefore requiring self-control to maintain attention on the task. Three experiments (Experiment 1, N=60; Experiment 2, N=61; Experiment 3, N=59) are reported that examined whether boredom at T1 predicted self-control at T2. A simple Go/No-Go task was used at T1. The ratio of Go to No-Go trials was changed across experiments to explore how the properties of the boring task impacted the association between boredom and self-control. When responding was frequent, increased boredom at T1 was associated with fewer anagrams correctly solved (Experiment 1 and 3), and more self-reported fatigue at T2 (Experiment 1), consistent with boredom leading to ego-depletion. However, when responding was infrequent (Experiment 2), increased boredom at T1 was associated with more correctly solved anagrams at T2, suggesting that the properties of a boring task change the psychological outcome that task has on self-control. Author Keywords: attention, boredom, ego-depletion, executive function, self-control
Executive Function as a Predictor of Emotional, Behavioural, and Social Competence Problems in Children with Epilepsy
The study aimed to examine the association between different components of executive function (EF) and emotional, behavioural, and social competence problems (EBSP) in children with epilepsy. Although there is evidence of an association between EBSP and EF in typically developing children, little research has examined this relation in children with epilepsy. The sample comprised of 42 children with epilepsy, aged 6.0 to 18.1 years old. Results showed that EBSP were associated with EF in these children; however, different components of EF were related to different EBSP. Shifting was a significant predictor of emotional, behavioural, and social competence problems in children with epilepsy, whereas inhibition was a significant predictor of behavioural problems. This suggests that children with epilepsy, with different EF profiles may be at-risk for developing different types of problems. These results may aid researchers and clinicians with the development of new techniques to identify and treat children with EBSP. Author Keywords: behavioural problems, emotional problems, epilepsy, executive function, social competence
Executive Function, Emotion Regulation, and Social Problem Solving, in Adolescence and Early Adulthood
Research to date on social problem solving typically focuses on elementary school aged children. However, adolescents and young adults may experience more novel and emotionally complex social conflicts that require different skills to navigate them successfully. Previous research has highlighted executive function (EF) and emotion regulation as possible skills that help with social problem solving. The current study examined the potential relation between EF, emotion regulation, and social problem solving. The sample consisted of 174 participants with a mean age of 19.60 years. Results showed that the shifting component of EF was associated with being able to take different perspectives when coming up with a solution for a social conflict involving a romantic partner. Additionally, emotion regulation was associate with perspective taking in the overall social problem solving process with a romantic partner. These results suggest that both EF and emotion regulation are involved in the ability to take different perspectives during a social conflict in this age range. Author Keywords: Emotion Regulation, Executive Function, Social Problem Solving

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Format: 2024/05/21