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Stability Properties of Disease Models under Economic Expectations
Comprehending the dynamics of infectious diseases is very important in formulating public health policies to tackling their prevalence. Mathematical epidemiology (ME) has played a very vital role in achieving the above. Nevertheless, classical mathematical epidemiological models do not explicitly model the behavioural responses of individuals in the presence of prevalence of these diseases. Economic epidemiology (EE) as a field has stepped in to fill this gap by integrating economic and mathematical concepts within one framework. This thesis investigated two issues in this area. The methods employed are the standard linear analysis of stability of dynamical systems and numerical simulation. Below are the investigations and the findings of this thesis: Firstly, an investigation into the stability properties of the equilibria of EE models is carried out. We investigated the stability properties of modified EE systems studied by Aadland et al. [6] by introducing a parametric quadratic utility function into the model, thus making it possible to model the maximum number of contacts made by rational individuals to be determined by a parameter. This parameter in particular influences the level of utility of rational individuals. We have shown that if rational individuals have a range of possible contacts to choose from, with the maximum of the number of contacts allowable for these individuals being dependent on a parameter, the variation in this parameter tends to affect the stability properties of the system. We also showed that under the assumption of permanent recovery for disease coupled with individuals observing or not observing their immunity, death and birth rates can affect the stability of the system. These parameters also have effect on the dynamics of the EE SIS system. Secondly, an EE model of syphilis infectivity among &ldquo men who have sex with men &rdquo (MSM) in detention centres is developed in an attempt at looking at the effect of behavioural responses on the disease dynamics among MSM. This was done by explicitly incorporating the interplay of the biology of the disease and the behaviour of the inmates. We investigated the stability properties of the system under rational expectations where we showed that: (1) Behavioural responses to the prevalence of the disease affect the stability of the system. Therefore, public health policies have the tendency of putting the system on indeterminate paths if rational MSM have complete knowledge of the laws governing the motion of the disease states as well as a complete understanding on how others behave in the system when faced with risk-benefit trade-offs. (2) The prevalence of the disease in the long run is influenced by incentives that drive the utility of the MSM inmates. (3) The interplay between the dynamics of the biology of the disease and the behavioural responses of rational MSM tends to put the system at equilibrium quickly as compared to its counterpart (that is when the system is solely dependent on the biology of the disease) when subjected to small perturbation. Author Keywords: economic and mathematical epidemiology models, explosive path, indeterminate-path stability, numerical solution, health gap, saddle-path stability, syphilis,
Comparative Evaluation of Effective Population Size Genetic Estimation Methods in Wild Brook Trout (Salvelinus fontinalis) Populations
Effective population size (Ne) is a key concept in population genetics, evolutionary biology and conservation biology that describes an important facet of genetic diversity and the capacity of populations to respond to future evolutionary pressures. The importance of Ne in management and conservation of wild populations encouraged the development of numerous genetic estimators which rely on a variety of methods. Despite the number and diversity of available Ne methods, however, tests of estimator performance have largely relied on simulations, with relatively few tests based on empirical data. I used well-studied wild populations of brook trout (Salvelinus fontinalis) in Algonquin Park, Ontario as a model system to assess the comparative performance of multiple Ne estimation methods and programs, comparing the resultant Ne estimates against demographic population size estimates. As a first step, the genetic diversity and ancestry of wild brook trout populations was determined using 14 microsatellite loci. Genetic structure of brook trout populations showed variable contributions from historical supplemental stocking and also identified localized gene pools within and between watersheds, reflecting variable levels of connectivity and gene flow. Once the genetic ancestry and connectivity of populations had been resolved, single sample (point) and two samples (temporal) genetic estimators were used to estimate Ne of populations with pure native ancestry. Values obtained from genetic estimators utilizing both methods were variable within as well as among populations. Single sample (point) estimators were variable within individual populations, but substantially less than was observed among the temporal methods. The ratios of Ne to the estimated demographic population size (N) in small populations were substantially higher than in larger populations. Variation among estimates obtained from the different methods reflects varying assumptions that underlay the estimation algorithms. This research further investigated the effect of sampling effort and number of microsatellite loci used on Ne values obtained using the linkage disequilibrium (LD) estimation method. Ne estimates varied substantially among values generated from subsets of loci and genotyped individuals, highlighting the necessity for proper sampling design for efforts aiming to measure Ne. Despite the variation observed among and within estimation methods, the Ne concept is a valuable for the conservation and management of both exploited and endangered species. Author Keywords: Brook Trout, Effective population size, Genetic Diversity, Genetic Structure
Effect of SP600125 JNK Inhibitor on Cadmium-Treated Mouse Embryo Forelimb Bud Cells In Vitro
This study investigated the role of the JNK signaling pathway in cadmium-treated mouse embryo forelimb bud cells in vitro. Primary cultures of forelimb bud cells harvested at day 11 of gestation were pre-treated with JNK inhibitor SP600125, and incubated with or without CdCl2 for 15, 30, 60, 120 minutes and 24, 48 hours or 5 days. Endpoints of toxicity were measured through cell differentiation by Alcian Blue Assay and phosphorylation of JNK proteins by Western blot. The results demonstrated that, in the cell differentiation assay, inhibiting JNK activation by 20 μM SP600125 causes an enhanced toxic effect in limb cells and inhibits cell differentiation, whereas 2 μM decreases differentiated nodule numbers under both cadmium stress and normal conditions. In conclusion, the JNK pathway has an essential role in the differentiation processes of limb bud cells in normal growth conditions. Author Keywords: Cadmium, Cell Signaling, JNK, Limbs, Mouse Embryo, Teratology
AN INTEGRATED APPROACH TO WASTEWATER MANAGEMENT AND REUSE IN JORDAN
This research explores the obstacles Jordan is facing regarding the sustainable treatment and reuse of wastewater in the agricultural sector. It assesses the technical, socio-cultural, and political aspects of decision-making around water and wastewater management in Jordan by focusing on a case study involving wastewater usage in the Jordan Valley. It includes a literature review and interviews with representatives of key stakeholders. While at one level wastewater treatment is a technical process with technological solutions, a nuanced understanding of the non-technical challenges facing the wastewater treatment sector in Jordan is necessary. These challenges are inherently embedded in and contextualized by a series of historical, complex and dynamic political and socio-cultural issues involving stakeholders at local and national levels. Only through an interdisciplinary approach with real stakeholder engagement will meaningful solutions to these challenges be developed and implemented, and at least a portion of Jordan's water needs be meaningfully addressed. Author Keywords: Agriculture, Jordan Valley, Political challenges, Sociocultural challenges, Technical challenges, wastewater management
Remembering the "Home" through YouTube Cooking Videos
This thesis examines how food, culture and identity are linked to the idea of "home." Through a reading of oral narratives produced on the YouTube channel "ShowMetheCurry," I investigate how presenters Anuja and Hetal "write back" from a diasporic space in Texas, to the YouTube global public, and how food and cuisine, even in the age of globalization can be problematic in terms of representation of identities, work and space. I explore how the YouTube videos operate as a heterotopia, as what is presented to the audience in this medium is an embedding of spaces. The space that is projected through "ShowMetheCurry," that of Anuja and Hetal's own home kitchen, is then projected and viewed within the audiences' own spaces, in various locations around the world. What connects these spaces is an interest in cooking, and a longing to satiate culinary nostalgia. Author Keywords: Affect, Culinary nostalgia, Discourse analysis, Food culture, South Asian Diaspora, YouTube
Exploring Least Cost Path Analysis
Least cost path analysis is considered by many scholars as being a good proxy for studying movement and interactions between sites in the landscape. Although it is widely used, there are many limitations and challenges yet to be overcome concerning the reliability of the results. The examples used from the Göksu Valley during the late Roman Imperial rule emphasize the need to clearly understand how the tool works in generating least cost paths and how these can be interpreted and related to human movement. The resolution and accuracy of the elevation data used also play an important role in least cost path analysis and these depend on the topographical area being studied. New venues are constantly being sought and the success of any analysis depends on how the results are compared and tested in concert with data obtained from various sources and through more visually advanced mapping software. Author Keywords: GIS, Göksu Valley, Turkey, Late Roman period, Least cost path, Roads, Routes, Communication, Spatial analysis

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