Graduate Theses & Dissertations

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Exploring Characteristics of those Utilizing Different Modalities of Treatment for Substance Use Disorders
Substance use disorder (SUD) is a pervasive psychological disorder detrimentally impacting both individuals and society on a psychological, economic, and social level. The best protocol for treating SUD as well as what defines success in treatment is often debated in the research. However, researchers agree that different psychosocial factors can influence outcomes. The literature suggests that mood, dark personality traits (narcissism and psychopathy), social supports, and state of change may be associated with treatment for SUD. The current study explored whether these factors predicted the type of treatment (abstinence-based or harm reduction) individuals with SUD were in. The sample consisted of 37 participants in a 12-step abstinence-based program and 65 in a harm reduction program at a local hospital. Results indicated that those in abstinence-based groups reported significantly fewer symptoms of anxiety and depression, lower levels of narcissism and psychopathy, more social supports, and advanced stage of change in comparison to those attending a harm reduction program. In addition, depression, narcissism, and perceived social support were significant predictors of treatment group membership. These findings suggest that those involved in abstinence-based groups appear to experience overall more wellness than those in harm reduction. Although further research is needed to specify the relations among factors, this study is a step towards understanding the difference between people who utilize one program versus another. Author Keywords: Abstinence, Addiction, Harm Reduction, Personality, Treatment
Impaired contextual fear discrimination learning after long-term amygdala kindling
Cognitive impairments, such as memory loss, are a frequent and devastating co-morbidity associated with epilepsy. The neurobiological mechanisms through which recurrent seizures induce cognitive impairments are not well understood. New neurons born after seizures develop abnormal morphological and functional characteristics that promote network hyperexcitability and hippocampal dysfunction. Previously, we found that kindling dramatically increases the rate of neurogenesis at early stages of seizure development, followed by a long-term suppression at later stages. These changes in the rate of cell proliferation coincides with aberrant modifications in the migration, excitability, and functional integration of these new neurons. It has been suggested that the long-term consequences of seizure-induced neurogenesis contributes to the development of cognitive impairment seen in chronic epilepsy. However, direct experimental evidence has been limited. The present series of experiments sough to determine if blocking aberrant seizure-induced neurogenesis can reduce cognitive deficits associated with chronic epilepsy. Our findings suggest that chronic seizures impair the ability of rats to differentiate between similar contexts. In addition, blocking aberrant seizure-induced neurogenesis through treatment with the cytotoxic agent temozolomide was capable of preventing some of the deficits in context discrimination learning when neurogenesis levels were reduced to non-epileptic control levels. This research provides further support of targeting aberrant neurogenesis as a novel treatment to restore cognitive functioning in individuals living with epilepsy. Author Keywords: Amygdala kindling, Dentate gyrus, Hippocampus, Neurogenesis, Pattern separation, Seizures
Unbridled Potential
Recently, equine assisted learning (EAL) has emerged as a novel approach to building resiliency competencies in at-risk youth. This mixed-methods study presents evaluation results for an 8-week community-based EAL program with 83 young women (age 13-18 years) with a history of interpersonal trauma. Analyses examined changes in self-reported mental health symptoms (posttraumatic, depression) and resiliency factors (sense of mastery, sense of relatedness, emotion regulation) from pre- to post-test and at 1-month and 6-month follow-ups. Changes in outcomes were also correlated with intervention processes (attendance, session ratings) to see if program experiences were associated with differential outcomes. Results showed that EAL has potential in improving resiliency outcomes, at least for those participants who derived greater satisfaction and value from the sessions. Many improvements were sustained over the long term. Participants’ qualitative feedback provided insight into their subjective experiences and highlighted the unique role that horses played in the EAL process. Author Keywords: Emotion Regulation, Equine Assisted Learning, Experiential Learning, Resilience, Sense of Mastery, Sense of Relatedness
Endocannabinoid Treatment for the Behavioural and Histopathological Alterations of Epilepsy
Epilepsy is associated with a variety of cognitive, emotional, and pain-related symptoms, such as impaired memory and learning, increased risk of anxiety and depression, and increased pain sensitivity. Unfortunately, these symptoms are generally untreated with typical pharmacological interventions, which tend to target seizure activity (i.e., ictogenesis) and not the subsequent histopathological and behavioural alterations resulting from epilepsy (i.e., epileptogenesis). Evidence has demonstrated that targeting the endocannabinoid system can alleviate seizure symptoms as well as cognitive, emotional, and pain-related impairments independent of epilepsy. However, research examining the use of endocannabinoid-based treatment for these behavioural symptoms when they are associated with epilepsy is sparse. In the following thesis, two animal models of epilepsy, several behavioural assessments, and immunohistochemical techniques are utilized to assess the effectiveness of endocannabinoid-based treatment for epilepsy’s interictal symptoms. The findings expand our knowledge and offer encouraging evidence for the usefulness of endocannabinoid-based treatment as an epileptogenesis-targeting pharmacological intervention. Author Keywords: animal models, endocannabinoid system, histopathological alterations, interictal symptoms, temporal lobe epilepsy, treatment
Emotional Intelligence and Bullying Victimization
Previous research has found that bullying and victimization is related to poor socioemotional competencies. The present study examined the relationship between emotional intelligence (EI) and bullying and victimization in a large community-based sample of adolescents. Specifically, we explored the EI of bullies, victims, bully-victims, and those uninvolved. We also examined whether the relationship between EI and types of bullying and victimization activities were consistent across age and gender. We found that stress management and interpersonal skills are important EI dimensions to predicting both bullying and victimization. Moreover, intrapersonal skills were predictive of boys’ bullying behaviours and adaptability was the strongest EI dimension in bullies and victims. Age did not contribute much to the overall prediction of bullying and victimization in either gender. Results are discussed in terms of future implications regarding anti-bullying interventions. Author Keywords: Adolescents, age, Bullying, Emotional Intelligence, gender, social emotional competencies
Executive Function as a Predictor of Emotional, Behavioural, and Social Competence Problems in Children with Epilepsy
The study aimed to examine the association between different components of executive function (EF) and emotional, behavioural, and social competence problems (EBSP) in children with epilepsy. Although there is evidence of an association between EBSP and EF in typically developing children, little research has examined this relation in children with epilepsy. The sample comprised of 42 children with epilepsy, aged 6.0 to 18.1 years old. Results showed that EBSP were associated with EF in these children; however, different components of EF were related to different EBSP. Shifting was a significant predictor of emotional, behavioural, and social competence problems in children with epilepsy, whereas inhibition was a significant predictor of behavioural problems. This suggests that children with epilepsy, with different EF profiles may be at-risk for developing different types of problems. These results may aid researchers and clinicians with the development of new techniques to identify and treat children with EBSP. Author Keywords: behavioural problems, emotional problems, epilepsy, executive function, social competence
Role of Multiple Nights of Sleep in the Consolidation of an Engaging and Complex Motor Learning Task
The present study examined the role of multiple nights of sleep in the consolidation of a complex motor learning task. Participants were 24 Trent undergraduates, 12 in the learning group (Mage = 20.33, SD = 1.87, 10 female) and 12 in the control group (Mage = 21.92, SD = 3.42, 7 female). Participants underwent 5 consecutive nights of polysomnographic recordings, with a Rock Band learning session on the third night. A series of 2(group)x4(night) ANOVAs were performed on the sleep variables. Interactions were found in the number of spindles detected at Pz, F(333) = 9.19, p <.01, and in the density of spindles detected at Pz, F(3,33) = 4.06, p <.05. The pattern of changes from baseline was significantly different between the two groups; spindles increased in the learning group and decreased in the control group. The novel finding was that spindle number/density remained elevated at the third post-learning night of sleep. Author Keywords: Motor Learning, Procedural Memory, Sleep, Sleep Spindles
Sextual Consent
The purpose of the current study was to explore the relationships between sexting, perceptions of sexual consent, and nonconsensual sexual experiences (NSEs). Participants consisted of 100 community members and 851 undergraduate students enrolled at Trent University. It was found that males were more likely than females to interpret ambiguous sexual scenarios as consensual, but consent perceptions were not influenced by sexting. When examining past personal experiences, males interpreted received sext messages as an indicator of consent significantly more than females, while females were more likely to interpret received messages as more harassing. NSEs were significantly related to sexting behaviours: those who engage in sexting were more likely to also have experienced a NSE, and 20.5% of participants in the current study reported having experienced a NSE with a consensual sexting partner. The current study has important implications for the future of sexting research, practice, and policy. Author Keywords: nonconsensual sexual experiences, sexting, sexual assault, sexual consent, sexual harassment
Comparison of Nature Activities
Research shows spending time in nature can result in many positive effects, including improving mood, connection to nature, and environmental concern. Certain activities may increase these positive effects of nature exposure. Citizen science (non-scientists collecting data to contribute to science) and environmental education (receiving information about the environment) are two potential ways to boost the positive effects of nature exposure. But little research has been done comparing citizen science with environmental education. To address this gap in knowledge, undergraduate participants were randomly assigned to spend five minutes outside daily, for two weeks, either simply observing nature, looking for birds, or looking for and recording bird sightings. Over time, all groups experienced improvements in mood, connection to nature, and environmental concern. However, connection to nature increased the most in people who simply observed nature. Unexpectedly, simply spending time in nature was the most effective intervention. Limitations and future directions are discussed. Author Keywords: Citizen Science, Emotional Well-Being, Environmental Concern, Environmental Education, Nature Exposure, Nature Relatedness
How Do We Let the Players Play and Keep Them Safe? The Issue of Problematic Beliefs in the Prevention of Concussion Injury
Athletes’ concussion risk is part of a complex system of personal and contextual factors. This study differentiated athletes based on attitudes and intentions towards protective behaviours. A cross-sectional survey design was used to sample varsity athletes. Three intention response subgroups (indifferent, reactive, and proactive) were identified. The indifferent group (28%) reported little-to-no intent to engage in risk reduction behaviours. These athletes reported lower belief in the efficacy of concussion management behaviours and greater risk acceptance attitudes. The proactive group (32%) reported intent to actively reduce personal concussion risk through engaging in behaviours such as confronting aggressive opponents about the risk they pose to others. The reactive group (40%) only reported intent to engage in concussion management behaviours. Indifferent athletes had the highest likelihood of concussion exposure followed by reactive athletes. The proactive athletes had the lowest likelihood. Concussion programs must address beliefs and intentions towards protective behaviours to improve effectiveness. Author Keywords: Athlete, Attitudes, Concussion, Injury Prevention, Intentions, Risk
Altered Hippocampal Regulation of Immediate Early Genes after Pentylenetetrazol-Induced Seizures
Seizures induce long-term changes in gene expression in the hippocampus. Experimental evidence has demonstrated a significant effect of epileptic activity on the activity of neurons that participate in complex cognitive and behavioural processes. The present series of experiments involving kindling with subconvulsive doses of PTZ demonstrates a link between seizures and altered immediate early gene expression within the hippocampus and dentate gyrus. In addition, newborn hippocampal neurons were shown to have decreased induction of plasticity-related genes, suggesting deficits in activity-dependent recruitment. These findings may shed light on the mechanisms underlying epileptogenesis and epilepsy-related hippocampal dysfunction in human patients. Author Keywords: hippocampus, IEGs, kindling, neurogenesis, seizures
Comparison of Dehydration Techniques for Acute Weight Management in Rowing
Mild sauna dehydration and fluid abstinence were investigated as weight loss strategies for lightweight rowers. Rowers (N=12) performed a power test, an incremental VO2max test, and a visuomotor battery: once euhydrated, once following sauna dehydration (SAU), and once following fluid abstinence and then sauna dehydration (FA). The percent body mass change (%BMC) achieved, %BMC attributable to sauna dehydration, and %BMC attributable to fluid abstinence were used within linear mixed effects models to predict hydration and performance variables. Sauna and overnight dehydration exerted indistinguishable effects on plasma osmolality, urine osmolality and thirst (p > .05). Fluid abstinence but not sauna dehydration was related to lower power production on the power test (b = 12.14W / 1%BMC, FA = 673.46 ± 79.50, SAU = 683.33 ± 72.08, p = .029), a lower total wattage produced on the incremental VO2max test (b = 4261.51W / 1%BMC, FA = 71029.58 ± 16256.56, SAU = 74001.50 ± 14936.56, p = .006), lower wattages at 2 mmol/L (b = 27.84W / 1%BMC, FA = 180.74 ± 40.27, SAU = 190.82 ± 50.79, p < .001) and 4 mmol/L (b = 20.45W / 1%BMC, FA = 221.90 ± 52.62, SAU = 238.89 ± 40.78, p = .002) blood lactate, and slower movement time on a visuomotor task (b = -38.06ms / 1%BMC, p = .004). Mild fluid abstinence but not sauna dehydration reduces rowing performance when two-hour rehydration is allowed. Author Keywords: crew, fluid, hydration, lightweight, sauna, weight

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Graduate student theses produced at Trent University. You may also browse theses and dissertations by year, program, or author.

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