Skip to content

Graduate Theses & Dissertations

: Altered Hippocampal Regulation of Immediate Early Genes after Pentylenetetrazol-Induced Seizures; Seizures induce long-term changes in gene expression in the hippocampus. Experimental evidence has demonstrated a significant effect of epileptic activity on the activity of neurons that participate in complex cognitive and behavioural processes. The present series of experiments involving kindling with subconvulsive doses of PTZ demonstrates a link between seizures and altered immediate early gene expression within the hippocampus and dentate gyrus. In addition, newborn hippocampal neurons were shown to have decreased induction of plasticity-related genes, suggesting deficits in activity-dependent recruitment. These findings may shed light on the mechanisms underlying epileptogenesis and epilepsy-related hippocampal dysfunction in human patients. Author Keywords: hippocampus, IEGs, kindling, neurogenesis, seizures

In collections

Trent University Digital Collections

Search Our Digital Collections

Advanced Search

Query

(-) *:*

Sort Results

Display